Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

被引：10

作者：

Ding, Derong ^{[1
]}

Lichtenwalter, Katerina ^{[1
]}

Pi, Hualiang ^{[1
]}

Mobashery, Shahriar ^{[1
]}

Chang, Mayland ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 09期

关键词：

MODULATORS; EXPRESSION; ROLES; NMR;

D O I：

10.1039/c4md00172a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compound 2 was a potent broad-spectrum inhibitor, notwithstanding that it is used as a selective one.

引用

页码：1381 / 1383

页数：3

共 25 条

[1]

Absence or Inhibition of Matrix Metalloproteinase-8 Decreases Ventilator-Induced Lung Injury [J].

Albaiceta, Guillermo M. ;

Gutierrez-Fernandez, Ana ;

Garcia-Prieto, Emilio ;

Puente, Xose S. ;

Parra, Diego ;

Astudillo, Aurora ;

Campestre, Cristina ;

Cabrera, Sandra ;

Gonzalez-Lopez, Adrian ;

Fueyo, Antonio ;

Taboada, Francisco ;

Lopez-Otin, Carlos .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2010, 43 (05) :555-563

[2]

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor [J].

Bonfil, RD ;

Sabbota, A ;

Nabha, S ;

Bernardo, MM ;

Dong, Z ;

Meng, H ;

Yamamoto, H ;

Chinni, SR ;

Lim, IT ;

Chang, M ;

Filetti, LC ;

Mobashery, S ;

Cher, ML ;

Fridman, R .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (11) :2721-2726

[3]

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia [J].

Cui, Jiankun ;

Chen, Shanyan ;

Zhang, Chunyang ;

Meng, Fanjun ;

Wu, Wei ;

Hu, Rong ;

Hadass, Or ;

Lehmidi, Tareq ;

Blair, Gregory J. ;

Lee, Mijoon ;

Chang, Mayland ;

Mobashery, Shahriar ;

Sun, Grace Y. ;

Gu, Zezong .

MOLECULAR NEURODEGENERATION, 2012, 7

[4]

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury [J].

Dejonckheere, Eline ;

Vandenbroucke, Roosmarijn E. ;

Libert, Claude .

DRUG DISCOVERY TODAY, 2011, 16 (17-18) :762-778

[5]

Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice [J].

Folgueras, Alicia R. ;

Fueyo, Antonio ;

Garcia-Suarez, Olivia ;

Cox, Jennifer ;

Astudillo, Aurora ;

Tortorella, Paolo ;

Campestre, Cristina ;

Gutierrez-Fernandez, Ana ;

Fanjul-Fernandez, Miriam ;

Pennington, Caroline J. ;

Edwards, Dylan R. ;

Overall, Christopher M. ;

Lopez-Otin, Carlos .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (14) :9465-9474

[6]

Expression of Matrix Metalloproteases by Fibrocytes Possible Role in Migration and Homing [J].

Garcia-de-Alba, Carolina ;

Becerril, Carina ;

Ruiz, Victor ;

Gonzalez, Yolanda ;

Reyes, Silvia ;

Garcia-Alvarez, Jorge ;

Selman, Moises ;

Pardo, Annie .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (09) :1144-1152

[7]

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting [J].

Gialeli, Chrisostomi ;

Theocharis, Achilleas D. ;

Karamanos, Nikos K. .

FEBS JOURNAL, 2011, 278 (01) :16-27

[8]

A Chemical Biological Strategy to Facilitate Diabetic Wound Healing [J].

Gooyit, Major ;

Peng, Zhihong ;

Wolter, William R. ;

Pi, Hualiang ;

Ding, Derong ;

Hesek, Dusan ;

Lee, Mijoon ;

Boggess, Bill ;

Champion, Matthew M. ;

Suckow, Mark A. ;

Mobashery, Shahriar ;

Chang, Mayland .

ACS CHEMICAL BIOLOGY, 2014, 9 (01) :105-110

[9]

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia [J].

Gu, ZZ ;

Cui, J ;

Brown, S ;

Fridman, R ;

Mobashery, S ;

Strongin, AY ;

Lipton, SA .

JOURNAL OF NEUROSCIENCE, 2005, 25 (27) :6401-6408

[10]

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion [J].

Gutierrez-Fernandez, Ana ;

Fueyo, Antonio ;

Folgueras, Alicia R. ;

Garabaya, Cecilia ;

Pennington, Caroline J. ;

Pilgrim, Simon ;

Edwards, Dylan R. ;

Holliday, Deborah L. ;

Jones, J. Louise ;

Span, Paul N. ;

Sweep, Fred C. G. J. ;

Puente, Xose S. ;

Lopez-Otin, Carlos .

CANCER RESEARCH, 2008, 68 (08) :2755-2763

← 1 2 3 →