Effects of Inula britannica on the production of antibodies and cytokines and on T cell differentiation in C57BL/6 mice immunized by ovalbumin

被引：18

作者：

Song, QH ^{[1
]}

Kobayashi, T ^{[1
]}

Hong, T ^{[1
]}

Cyong, JC ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, Tokyo 1138655, Japan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2002年 / 30卷 / 2-3期

关键词：

Inula Britannica; C57BL/6; mice; cytokine; B cell; T cell; antibody production;

D O I：

10.1142/S0192415X02000211

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In this study, we investigated the effects of Inula Britannica on the production of antibodies against ovalbumin, and the differentiation of T cells, in C57BL/6 mice. The oral administration of Inula Britannica suppressed IL-4 and IL-6 production in lymphocytes collected from an inguinal lymph node in the immunized leg. On the other hand, the intraperitoneal administration of Inula Britannica suppressed IgG1 production, the ratio of IFN-gamma(+)IL-4(-)/IFN-gamma-IL-4(+) cells and cytokine production of IL-6. It was presumed that the effects of Inula Britannica on the production of antibodies were induced by regulation of the balance of Th1 and Th2. Further, IL-4 and IL-6 production by lymphocytes collected from an inguinal lymph node in the immunized leg were suppressed, and therefore production of antibodies was suppressed.

引用

页码：297 / 305

页数：9

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