cis-cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues:: stereochemical dependence of DNA/RNA hybridization

被引:31
作者
Govindaraju, T [1 ]
Kumar, VA [1 ]
Ganesh, KN [1 ]
机构
[1] Natl Chem Lab, Div Organ Chem Synth, Pune 411008, Maharashtra, India
关键词
D O I
10.1039/b317000d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
DNA/RNA hybridization studies of PNA-T oligomers with cis(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.
引用
收藏
页码:860 / 861
页数:2
相关论文
共 12 条
[1]   A NUCLEIC-ACID TRIPLE-HELIX FORMED BY A PEPTIDE NUCLEIC-ACID DNA COMPLEX [J].
BETTS, L ;
JOSEY, JA ;
VEAL, JM ;
JORDAN, SR .
SCIENCE, 1995, 270 (5243) :1838-1841
[2]   Novel antisense and peptide nucleic acid strategies for controlling gene expression [J].
Braasch, DA ;
Corey, DR .
BIOCHEMISTRY, 2002, 41 (14) :4503-4510
[3]   NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC-ACID COMPLEXED WITH RNA [J].
BROWN, SC ;
THOMSON, SA ;
VEAL, JM ;
DAVIS, DG .
SCIENCE, 1994, 265 (5173) :777-780
[4]   PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES [J].
EGHOLM, M ;
BUCHARDT, O ;
CHRISTENSEN, L ;
BEHRENS, C ;
FREIER, SM ;
DRIVER, DA ;
BERG, RH ;
KIM, SK ;
NORDEN, B ;
NIELSEN, PE .
NATURE, 1993, 365 (6446) :566-568
[5]   Solution structure of a peptide nucleic acid DNA duplex [J].
Eriksson, M ;
Nielsen, PE .
NATURE STRUCTURAL BIOLOGY, 1996, 3 (05) :410-413
[6]   A NOVEL AND EFFICIENT SYNTHESIS OF (+)- AND (-)-TRANS-2-AMINOCYCLOHEXANOL BY ENZYMATIC-HYDROLYSIS [J].
FABER, K ;
HONIG, H ;
SEUFERWASSERTHAL, P .
TETRAHEDRON LETTERS, 1988, 29 (16) :1903-1904
[7]   Peptide nucleic acids: Analogs and derivatives [J].
Ganesh, KN ;
Nielsen, PE .
CURRENT ORGANIC CHEMISTRY, 2000, 4 (09) :931-943
[8]   (1S,2R/1R,2S)-aminocyclohexyl glycyl thymine PNA:: Synthesis, monomer crystal structures, and DNA/RNA hybridization studies [J].
Govindaraju, T ;
Gonnade, RG ;
Bhadbhade, MM ;
Kumar, VA ;
Ganesh, KN .
ORGANIC LETTERS, 2003, 5 (17) :3013-3016
[9]   ENZYMATIC RESOLUTIONS OF CYCLIC AMINO ALCOHOL PRECURSORS [J].
HONIG, H ;
SEUFERWASSERTHAL, P ;
FULOP, F .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (12) :2341-2345
[10]  
Kumar VA, 2002, EUR J ORG CHEM, V2002, P2021