Progesterone as a neurosteroid: Actions within the nervous system

被引:68
作者
Baulieu, EE [1 ]
Schumacher, M [1 ]
Koenig, H [1 ]
JungTestas, I [1 ]
Akwa, Y [1 ]
机构
[1] UNIV BORDEAUX 1, DEV NEUROBIOL LAB, BORDEAUX, FRANCE
关键词
steroids; neurosteroids; progesterone; estradiol; nerve regeneration; myelin; Schwann cells; oligodendrocytes; astrocytes;
D O I
10.1007/BF02088173
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
1. Some progesterone is synthesized within both the central and the peripheral nervous systems, where it regulates neurotransmission and important glial functions, such as the formation of myelin, Progesterone can thus be designated a ''neurosteroid.'' 2. Steroids act not only on the brain, but also on peripheral nerves, which offer many advantages to study the biological significance of locally produced neurosteroids: their remarkable plasticity and relatively simple structure. 3. By using the regenerating mouse sciatic nerve as a model, we have shown that progesterone synthesized by rat Schwann cells promotes the formation of new myelin sheaths, Progesterone also increases the number of myelinated axons when added at a low concentration to cocultures of Schwann cells and sensory neurons. 4. These findings show a function on myelination for locally produced progesterone and suggest a new pharmacological approach of myelin repair.
引用
收藏
页码:143 / 154
页数:12
相关论文
共 50 条
[1]  
AKWA Y, 1993, CR ACAD SCI III-VIE, V316, P410
[2]   ASTROCYTES AND NEUROSTEROIDS - METABOLISM OF PREGNENOLONE AND DEHYDROEPIANDROSTERONE - REGULATION BY CELL-DENSITY [J].
AKWA, Y ;
SANANES, N ;
GOUEZOU, M ;
ROBEL, P ;
BAULIEU, EE ;
LEGOASCOGNE, C .
JOURNAL OF CELL BIOLOGY, 1993, 121 (01) :135-143
[3]  
Baulieu E. E., 1981, Steroid Hormone Regulation of the Brain, P3
[4]   NEUROSTEROIDS - A NEW FUNCTION IN THE BRAIN [J].
BAULIEU, EE .
BIOLOGY OF THE CELL, 1991, 71 (1-2) :3-10
[5]  
BIZZOZERO OA, 1991, J BIOL CHEM, V266, P17092
[6]   NEURONS REGULATE SCHWANN-CELL GENES BY DIFFUSIBLE MOLECULES [J].
BOLIN, LM ;
SHOOTER, EM .
JOURNAL OF CELL BIOLOGY, 1993, 123 (01) :237-243
[7]  
CHADWICK D, 1990, CIBA FDN S, V153
[8]   PREGNENOLONE AND ITS SULFATE ESTER IN THE RAT-BRAIN [J].
CORPECHOT, C ;
SYNGUELAKIS, M ;
TALHA, S ;
AXELSON, M ;
SJOVALL, J ;
VIHKO, R ;
BAULIEU, EE ;
ROBEL, P .
BRAIN RESEARCH, 1983, 270 (01) :119-125
[9]   CONTRIBUTION OF AXONAL-TRANSPORT TO THE RENEWAL OF MYELIN PHOSPHOLIPIDS IN PERIPHERAL-NERVES .1. QUANTITATIVE AUTORADIOGRAPHIC STUDY [J].
DROZ, B ;
DIGIAMBERARDINO, L ;
KOENIG, HL .
BRAIN RESEARCH, 1981, 219 (01) :57-71
[10]   PERIPHERAL-NERVE REGENERATION [J].
FAWCETT, JW ;
KEYNES, RJ .
ANNUAL REVIEW OF NEUROSCIENCE, 1990, 13 :43-60