The first total synthesis of the proposed structure of Montiporyne E

被引：7

作者：

Collison, Christina G. ^{[1
]}

Chen, Jian ^{[1
]}

Walvoord, Ryan ^{[1
]}

机构：

[1] Rochester Inst Technol, Dept Chem, Rochester, NY 14623 USA

来源：

SYNTHESIS-STUTTGART | 2006年 / 14期

关键词：

synthesis; Beckmann; lactams; coupling reactions; alkynes;

D O I：

10.1055/s-2006-942441

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Montiporyne E, a novel diacetylenic lactam isolated from the stony coral Montipora sp., was shown to exhibit cytotoxicity against certain solid tumor cells. Construction of a suitably functionalized alpha,beta-unsaturated lactam for palladium-catalyzed couplings was realized via a Beckmann rearrangement. Subsequent Sonagoshira coupling with a known alkyne chain efficiently afforded the alleged structure of the natural product.

引用

页码：2319 / 2322

页数：4

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