Impairment of neuromuscular transmission in a subgroup of migraine patients

被引：30

作者：

Ambrosini, A ^{[1
]}

de Noordhout, AM ^{[1
]}

Alagona, G ^{[1
]}

Dalpozzo, F ^{[1
]}

Schoenen, J ^{[1
]}

机构：

[1] Univ Liege, Dept Neurol, Headache Unit, CHR Citadelle, B-4000 Liege, Belgium

来源：

NEUROSCIENCE LETTERS | 1999年 / 276卷 / 03期

关键词：

migraine; P/Q Ca2+ channels; single fiber electromyography; neuromuscular transmission; familial hemiplegic migraine;

D O I：

10.1016/S0304-3940(99)00820-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where-they control stimulation-induced acetylcholine release. Using single fiber EMG recordings we were able to demonstrate subclinical abnormalities of neuromuscular transmission in a subgroup of patients suffering from migraine with aura. This could be related to genetic abnormalities of P/Q Ca2+ channels in certain patients suffering from migraine with aura, which needs to be explored by proper genetic analyses. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：201 / 203

页数：3

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