Neurotrophins: Mediators and modulators of pain

被引:668
作者
Pezet, Sophie [1 ]
McMahon, Stephen B. [1 ]
机构
[1] Kings Coll London, London Pain Consortium, Wolfson Ctr Age Related Dis, London SE1 1UL, England
基金
英国惠康基金;
关键词
NGF; BDNF; NT-3; NT-4; hyperalgesia; plasticity;
D O I
10.1146/annurev.neuro.29.051605.112929
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal survival and growth. Over the past decade, considerable evidence has accumulated from both humans and animals that one neurotrophin, nerve growth factor (NGF), is a peripheral pain mediator, particularly in inflammatory pain states. NGF is upregulated in a wide variety of inflammatory conditions, and NGF-neutralizing molecules are effective analgesic agents in many models of persistent pain. Such molecules are now being evaluated in clinical trials. NGF regulates the expression of a second neurotrophin, brain-derived neurotrophic factor (BDNF), in nociceptors. BDNF is released when nociceptors are activated, and it acts as a central modulator of pain. The chapter reviews the evidence for these roles (and briefly the effects of other neurotrophins), the range of conditions under which they act, and their mechanism of action.
引用
收藏
页码:507 / 538
页数:32
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