Endocan-A Novel Inflammatory Indicator in Newly Diagnosed Patients With Hypertension: A Pilot Study

被引：144

作者：

Balta, Sevket ^{[1
]}

Mikhailidis, Dimitri P. ^{[2
]}

Demirkol, Sait ^{[3
]}

Ozturk, Cengiz ^{[3
]}

Kurtoglu, Ertugrul ^{[4
]}

Demir, Mustafa ^{[3
]}

Celik, Turgay ^{[3
]}

Turker, Turker ^{[5
]}

Iyisoy, Atila ^{[3
]}

机构：

[1] Eskisehir Mil Hosp, Dept Cardiol, Eskisehir, Turkey

[2] UCL, Med Sch London, Dept Clin Chem, London WC1E 6BT, England

[3] Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey

[4] Malatya State Hosp, Dept Cardiol, Malatya, Turkey

[5] Gulhane Mil Med Acad, Dept Epidemiol, Ankara, Turkey

来源：

ANGIOLOGY | 2014年 / 65卷 / 09期

关键词：

endocan; inflammation; newly diagnosed hypertension; CELL-SPECIFIC MOLECULE-1; CARDIOVASCULAR RISK; BLOOD-PRESSURE; TARGET; ASSOCIATION; MARKER; ESM-1;

D O I：

10.1177/0003319713513492

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell-specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we assessed serum levels of endocan in newly diagnosed patients with untreated essential hypertension (HT). A total of 18 patients with HT and 23 normotensive control participants were included in the study. Serum endocan levels, carotid intima-media thickness (cIMT), and high-sensitivity C-reactive protein (hsCRP) were measured. Serum endocan levels were significantly higher in the HT group (P < .001). In patients with HT, serum endocan levels correlated positively with cIMT and hsCRP (r = .551, P < .001 and r = .644, P < .001, respectively). Our findings suggest that circulating endocan levels represent a new marker in patients with essential HT. Endocan may be a surrogate endothelial dysfunction marker and may have a functional role in endothelium-dependent pathological disorders.

引用

页码：773 / 777

页数：5

共 24 条

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