学术探索
学术期刊
新闻热点
数据分析
智能评审

Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation

被引：43
作者：
Sapin, V
Bouillet, P
Oulad-Abdelghani, M
Dastugue, B
Chambon, P
Dollé, P
机构：
[1] Coll France, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM,ULP, F-67404 Illkirch Graffenstaden, France
[2] Fac Med, Unite INSERM 384, Lab Biochim Med, F-63001 Clermont Ferrand, France
来源：
MECHANISMS OF DEVELOPMENT | 2000年 / 92卷 / 02期
关键词：
AP-2; gamma; ephrinB1; in situ hybridization; Meis2; mouse embryo; placenta; retinoids; trophoblast;
D O I：
10.1016/S0925-4773(00)00241-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several retinoid binding proteins and nuclear receptors are specifically expressed in murine placenta. However, little is known about molecular events and target genes regulated by retinoids during placentation. Here, we report that several retinoic acid-inducible (Stra) genes, originally isolated by a differential screening procedure, exhibit specific expression patterns in mouse placental tissues. Three Stra genes, including the ephrinB1 receptor tyrosine kinase ligand, are prominently expressed in the regions of exchanges between maternal and embryonic circulations, i.e. the yolk sac and/or the labyrinthine zone of the mature placenta. The Meis2 homeobox gene appears to be specifically expressed in maternally-derived cell populations. Three other Stra gents, including the AP-2-related gene AP-2 gamma, are differentially expressed in the trophoblastic cell lineage. Thus, retinoids may regulate various signaling pathways in specific placental cell-types. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：295 / 299
页数：5
相关论文
共 35 条
[1]  
BAXTER JD, 1991, RECENT PROG HORM RES, V47, P211
[2]   Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein [J].
Bouillet, P ;
Sapin, V ;
Chazaud, C ;
Messaddeq, N ;
Decimo, D ;
Dolle, P ;
Chambon, P .
MECHANISMS OF DEVELOPMENT, 1997, 63 (02) :173-186
[3]   SEQUENCE AND EXPRESSION PATTERN OF THE STRA7 (GBX-2) HOMEOBOX-CONTAINING GENE INDUCED BY RETINOIC ACID IN P19 EMBRYONAL CARCINOMA-CELLS [J].
BOUILLET, P ;
CHAZAUD, C ;
OULADABDELGHANI, M ;
DOLLE, P ;
CHAMBON, P .
DEVELOPMENTAL DYNAMICS, 1995, 204 (04) :372-382
[4]   A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid [J].
Bouillet, P ;
OuladAbdelghani, M ;
Ward, SJ ;
Bronner, S ;
Chambon, P ;
Dolle, P .
MECHANISMS OF DEVELOPMENT, 1996, 58 (1-2) :141-152
[5]   EFFICIENT CLONING OF CDNAS OF RETINOIC ACID-RESPONSIVE GENES IN P19 EMBRYONAL CARCINOMA-CELLS AND CHARACTERIZATION OF A NOVEL MOUSE GENE, STRA1 (MOUSE LERK-2/EPLG2) [J].
BOUILLET, P ;
OULADABDELGHANI, M ;
VICAIRE, S ;
GARNIER, JM ;
SCHUHBAUR, B ;
DOLLE, P ;
CHAMBON, P .
DEVELOPMENTAL BIOLOGY, 1995, 170 (02) :420-433
[6]   Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins [J].
Chang, CP ;
Jacobs, Y ;
Nakamura, T ;
Jenkins, NA ;
Copeland, NG ;
Cleary, ML .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (10) :5679-5687
[7]   AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis [J].
Chazaud, C ;
OuladAbdelghani, M ;
Bouillet, P ;
Decimo, D ;
Chambon, P ;
Dolle, P .
MECHANISMS OF DEVELOPMENT, 1996, 54 (01) :83-94
[8]   RETINOIC ACID AND PATTERN-FORMATION IN VERTEBRATES [J].
CONLON, RA .
TRENDS IN GENETICS, 1995, 11 (08) :314-319
[9]   A COMPARATIVE STUDY OF FINE STRUCTURE OF TROPHOBLAST IN SEVERAL HEMOCHORIAL PLACENTAS [J].
ENDERS, AC .
AMERICAN JOURNAL OF ANATOMY, 1965, 116 (01) :29-&
[10]   Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta [J].
Giroux, S ;
Tremblay, M ;
Bernard, D ;
Cadrin-Girard, JF ;
Aubry, S ;
Larouche, L ;
Rousseau, S ;
Huot, J ;
Landry, J ;
Jeannotte, L ;
Charron, J .
CURRENT BIOLOGY, 1999, 9 (07) :369-372
1234