Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

被引：345

作者：

Bratton, SB ^{[1
]}

MacFarlane, M ^{[1
]}

Cain, K ^{[1
]}

Cohen, GM ^{[1
]}

机构：

[1] Univ Leicester, MRC Technol Unit, Leicester LE1 9HN, Leics, England

来源：

EXPERIMENTAL CELL RESEARCH | 2000年 / 256卷 / 01期

关键词：

caspases; apoptosome; Apaf-1; DISC; death domains;

D O I：

10.1006/excr.2000.4835

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caspases play a central role in the execution phase of apoptosis and are responsible for many of the morphological features normally associated with this form of cell death. Caspases can activate one another and consequently can initiate specific caspase cascades. Caspases-8 and -9 appear to be the apical caspases activated in death receptor- and mitochondrial stress-induced apoptosis, respectively. The role of large protein complexes in mediating these pathways is discussed. (C) 2000 Academic Press.

引用

页码：27 / 33

页数：7

共 41 条

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