Ex-vivo injection for implanting solid pulmonary nodules into porcine lungs for multi-slice CT

被引:19
作者
Bolte, H [1 ]
Müller-Hülsbeck, S [1 ]
Riedel, C [1 ]
Jahnke, T [1 ]
Inan, N [1 ]
Heller, M [1 ]
Biederer, J [1 ]
机构
[1] Univ Klinikum Schleswig Holstein, Radiol Diagnost Klin, D-24105 Kiel, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2004年 / 176卷 / 10期
关键词
lung nodule; lung neoplasm; diagnosis; multi-detector computed tomography; phantoms;
D O I
10.1055/s-2004-813558
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To develop a method for generating realistic pulmonary nodules that equal small pulmonary metastases and granulomas. Materials and Methods: A total of 70 artificial lesions were introduced into 5 inflated porcine lungs inside a dedicated chest phantom by high pressure injection of a fat-wax-Lipiodol mixture and scanned with 16-slice computed tomography (CT). Image evaluation by two experienced radiologists included analysis of morphology, nodule size and density. Results: The median nodule density was 78.8 Hounsfield units (HU), with 54 of 70 nodules (77.14%) judged typical of small lung metastases. Conclusion: Without inducing visible damage of lung parenchyma, the injection technique produces highly realistic pulmonary nodules for morphometry or nodule detection with CT.
引用
收藏
页码:1380 / 1384
页数:5
相关论文
共 15 条
[1]   Simulated pulmonary nodules implanted in a dedicated porcine chest phantom: Sensitivity of MR imaging for detection [J].
Biederer, J ;
Schoene, A ;
Freitag, S ;
Reuter, M ;
Heller, M .
RADIOLOGY, 2003, 227 (02) :475-483
[2]   Artificial thorax for MR imaging studies in porcine heart-lung preparations [J].
Biederer, J ;
Heller, M .
RADIOLOGY, 2003, 226 (01) :250-255
[3]   Sensitivity of MRI in detecting alveolar infiltrates: Experimental studies [J].
Biederer, J ;
Busse, I ;
Grimm, J ;
Reuter, M ;
Muhle, C ;
Freitag, S ;
Heller, M .
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2002, 174 (08) :1033-1039
[4]   Effect of breathing on the detection of in vivo simulated pulmonary nodules by spiral CT [J].
Coakley, FV ;
Cohen, MD ;
Johnson, MS ;
Gonin, R ;
Hanna, MP .
CLINICAL RADIOLOGY, 1998, 53 (07) :506-509
[5]   Maximum intensity projection images in the detection of simulated pulmonary nodules by spiral CT [J].
Coakley, FV ;
Cohen, MD ;
Johnson, MS ;
Gonin, R ;
Hanna, MP .
BRITISH JOURNAL OF RADIOLOGY, 1998, 71 (842) :135-140
[6]   Screening for early lung cancer with low-dose spiral CT: Prevalence in 817 asymptomatic smokers [J].
Diederich, S ;
Wormanns, D ;
Semik, M ;
Thomas, M ;
Lenzen, H ;
Roos, N ;
Heindel, W .
RADIOLOGY, 2002, 222 (03) :773-781
[7]   Detection of simulated chest lesions by using soft-copy reading: Comparison of an amorphous silicon flat-panel-detector system and a storage-phosphor system [J].
Goo, JM ;
Im, JG ;
Lee, HJ ;
Chung, MJ ;
Seo, JB ;
Kim, HY ;
Lee, YJ ;
Kang, JW ;
Kim, JH .
RADIOLOGY, 2002, 224 (01) :242-246
[8]   Detection of simulated pulmonary nodules by single-exposure dual-energy computed radiography of the chest: effect of a computer-aided diagnosis system (Part 2) [J].
Kido, S ;
Kuriyama, K ;
Kuroda, C ;
Nakamura, H ;
Ito, W ;
Shimura, K ;
Kato, H .
EUROPEAN JOURNAL OF RADIOLOGY, 2002, 44 (03) :205-209
[9]   Small pulmonary nodules: Volume measurement at chest CT - Phantom study [J].
Ko, JP ;
Rusinek, H ;
Jacobs, EL ;
Babb, JS ;
Betke, M ;
McGuinness, G ;
Naidich, DP .
RADIOLOGY, 2003, 228 (03) :864-870
[10]   Lung nodule detection and characterization with multislice CT [J].
Ko, JP ;
Naidich, DP .
RADIOLOGIC CLINICS OF NORTH AMERICA, 2003, 41 (03) :575-+