SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

被引：51

作者：

Ao, Qilin ^{[1
,2
]}

Su, Wenjing ^{[3
]}

Guo, Shuang ^{[4
]}

Cai, Lei ^{[1
,2
]}

Huang, Lei ^{[5
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Pathol, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathol, Wuhan 430030, Peoples R China

[3] Shandong Univ, Shandong Prov Hosp, Dept Pathol, Jinan 250021, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pathol, Wuhan 430030, Peoples R China

[5] Cent Hosp Wuhan, Dept Obstet & Gynecol, Wuhan 430014, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

INDUCIBLE FACTOR 1-ALPHA; FACTOR-1-ALPHA; RESISTANCE; OVEREXPRESSION; HIF1-ALPHA; STABILITY; PROTEIN; GROWTH; TUMORS; HIF-1;

D O I：

10.1038/srep16396

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1 alpha can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1 alpha is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1 alpha by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1 alpha and plays a negative role in ovarian cancer chemotherapy.

引用

页数：8

共 28 条

[1]

Sumoylation increases HIF-1 stability and its transcriptional activity [J].