Alternative splicing of LYT1 transcripts in Trypanosoma cruzi

被引:22
作者
Manning-Cela, R
González, A
Swindle, J
机构
[1] Infect Dis Res Inst, Seattle, WA 98104 USA
[2] IPN, Ctr Invest & Estudios Avanzados, Dept Biomed Mol, Mexico City 07738, DF, Mexico
[3] CSIC, Inst Parasitol & Biomed, Granada, Spain
关键词
D O I
10.1128/IAI.70.8.4726-4728.2002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
As a result of alternative trans splicing, three distinct LYT1 mRNAs are produced in Trypanosoma cruzi, two encoding the full-length LYT1 protein and the third encoding a truncated LYT1 protein lacking a possible signal sequence. Analysis of the three mRNAs in different developmental forms of the parasite revealed that the alternative processing events were regulated differently during the parasite life cycle.
引用
收藏
页码:4726 / 4728
页数:3
相关论文
共 12 条
[1]   UNEXPECTED POINT MUTATIONS ACTIVATE CRYPTIC 3' SPLICE SITES BY PERTURBING A NATURAL SECONDARY STRUCTURE WITHIN A YEAST INTRON [J].
DESHLER, JO ;
ROSSI, JJ .
GENES & DEVELOPMENT, 1991, 5 (07) :1252-1263
[2]   APPARENT GENERATION OF A SEGMENTED MESSENGER-RNA FROM 2 SEPARATE TANDEM GENE FAMILIES IN TRYPANOSOMA-CRUZI [J].
GONZALEZ, A ;
LERNER, TJ ;
HUECAS, M ;
SOSAPINEDA, B ;
NOGUEIRA, N ;
LIZARDI, PM .
NUCLEIC ACIDS RESEARCH, 1985, 13 (16) :5789-5804
[3]   MATURATION OF POLYCISTRONIC PRE-MESSENGER-RNA IN TRYPANOSOMA-BRUCEI - ANALYSIS OF TRANS SPLICING AND POLY(A) ADDITION AT NASCENT RNA TRANSCRIPTS FROM THE HSP70 LOCUS [J].
HUANG, J ;
VANDERPLOEG, LHT .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (06) :3180-3190
[4]   REQUIREMENT OF A POLYPYRIMIDINE TRACT FOR TRANSSPLICING IN TRYPANOSOMES - DISCRIMINATING THE PARP PROMOTER FROM THE IMMEDIATELY ADJACENT 3' SPLICE ACCEPTOR SITE [J].
HUANG, J ;
VANDERPLOEG, LHT .
EMBO JOURNAL, 1991, 10 (12) :3877-3885
[5]   Mutational analysis of 3′ splice site selection during trans-splicing [J].
Hummel, HS ;
Gillespie, RD ;
Swindle, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (45) :35522-35531
[6]   TRANSCRIPTION OF THE INTERGENIC REGIONS OF THE TUBULIN GENE-CLUSTER OF TRYPANOSOMA-BRUCEI - EVIDENCE FOR A POLYCISTRONIC TRANSCRIPTION UNIT IN A EUKARYOTE [J].
IMBODEN, MA ;
LAIRD, PW ;
AFFOLTER, M ;
SEEBECK, T .
NUCLEIC ACIDS RESEARCH, 1987, 15 (18) :7357-7368
[7]   SEQUENCE AND S1 NUCLEASE MAPPING OF THE 5' REGION OF THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE OF LEISHMANIA-MAJOR [J].
KAPLER, GM ;
ZHANG, K ;
BEVERLEY, SM .
NUCLEIC ACIDS RESEARCH, 1987, 15 (08) :3369-3383
[8]   LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi [J].
Manning-Cela, R ;
Cortés, A ;
González-Rey, E ;
Van Voorhis, WC ;
Swindle, J ;
González, A .
INFECTION AND IMMUNITY, 2001, 69 (06) :3916-3923
[9]   A COMMON PYRIMIDINE-RICH MOTIF GOVERNS TRANSSPLICING AND POLYADENYLATION OF TUBULIN POLYCISTRONIC PRE-MESSENGER-RNA IN TRYPANOSOMES [J].
MATTHEWS, KR ;
TSCHUDI, C ;
ULLU, E .
GENES & DEVELOPMENT, 1994, 8 (04) :491-501
[10]   POLYCISTRONIC TRANSCRIPTS IN TRYPANOSOMES AND THEIR ACCUMULATION DURING HEAT-SHOCK - EVIDENCE FOR A PRECURSOR ROLE IN MESSENGER-RNA SYNTHESIS [J].
MUHICH, ML ;
BOOTHROYD, JC .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) :3837-3846