Inorganic/organic salts as heterogeneous basic catalysts for cyanosilylation of carbonyl compounds

被引：56

作者：

He, B

Li, Y

Feng, XM ^{[1
]}

Zhang, GL

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

来源：

SYNLETT | 2004年 / 10期

关键词：

heterogeneous catalysis; potassium carbonate; cyanosilylation; cyanohydrins; carbonyl compounds;

D O I：

10.1055/s-2004-829569

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of TMSCN to carbonyl compounds catalyzed by K2CO3 as heterogeneous catalyst gave the corresponding cyanohydrin trimethylsilyl ethers from 20 minutes to 24 hours with 62% to 99% yields without solvent at room temperature. Moreover, it was found that chiral organic salts as heterogeneous catalysts also can catalyze the asymmetric version and afford the corresponding products with up to 99% yield and 12.4% ee.

引用

页码：1776 / 1778

页数：3

共 40 条

[1] The asymmetric addition of trimethylsilyl cyanide to ketones catalysed by a bimetallic, chiral (salen)titanium complex [J].