Asymmetric synthesis of alkyl 5-oxotetrahydrofuran-2-carboxylates by enantioselective hydrogenation of dialkyl 2-oxoglutarates over cinchona modified Pt/Al2O3 catalysts

被引：50

作者：

Balázsik, K

Szöri, K

Felföldi, K

Török, B

Bartók, M

机构：

[1] Hungarian Acad Sci, Organ Catalysis Res Grp, H-6720 Szeged, Hungary

[2] Attila Jozsef Univ, Dept Organ Chem, H-6720 Szeged, Hungary

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 07期

关键词：

D O I：

10.1039/b000390p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct asymmetric synthesis of chiral alkyl 5-oxo-tetrahydrofuran-2-carboxylates (up to 96% ee), which are important building blocks in the synthesis of natural products by heterogeneous cinchona-modified Pt-catalyzed hydrogenation of alpha-ketoglutaric acid esters and subsequent cyclization of hydroxy esters is described.

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页码：555 / 556

页数：2

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