Posttraining intra-basolateral amygdala scopolamine impairs food- and amphetamine-induced conditioned place preferences

被引：43

作者：

Schroeder, JP ^{[1
]}

Packard, MG ^{[1
]}

机构：

[1] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2002年 / 116卷 / 05期

关键词：

D O I：

10.1037//0735-7044.116.5.922

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present study investigated the role of cholinergic muscarinic receptor function within the basolateral amygdala memory in the consolidation of conditioned place preference (CPP) memory. Adult male Long-Evans rats were confined to treatment- or nontreatment-paired compartments for 30 min on 4 alternating days. After training, rats received intrabasolateral amygdala infusions of scopolamine (2.5 mug or 5.0 mug/0.5 mul) or saline. The rats were then given a 20-min test session, and the time spent in each of the compartments was recorded. Immediate posttraining (but not delayed 2 hr) scopolamine (5.0 mug) blocked acquisition of food- and amphetamine-induced CPPs. The findings indicate a time-dependent role for basolateral amygdala muscarinic receptors in memory consolidation underlying CPPs for natural and drug rewards.

引用

页码：922 / 927

页数：6

共 53 条

[1] SCH 23390 BLOCKS DRUG-CONDITIONED PLACE-PREFERENCE AND PLACE-AVERSION - ANHEDONIA (LACK OF REWARD) OR APATHY (LACK OF MOTIVATION) AFTER DOPAMINE-RECEPTOR BLOCKADE [J].