Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation

被引：190

作者：

Kometani, Kohei ^{[1
]}

Nakagawa, Rinako ^{[5
,6
]}

Shinnakasu, Ryo ^{[1
]}

Kaji, Tomohiro ^{[2
]}

Rybouchkin, Andrei ^{[3
]}

Moriyama, Saya ^{[1
,5
,6
]}

Furukawa, Koji ^{[7
]}

Koseki, Haruhiko ^{[4
]}

Takemori, Toshitada ^{[2
]}

Kurosaki, Tomohiro ^{[1
,5
,6
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Lab Lymphocyte Differentiat, Yokohama, Kanagawa 2300045, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Lab Immunol Memory, Yokohama, Kanagawa 2300045, Japan

[3] RIKEN, Res Ctr Allergy & Immunol, Res Unit Lymphocyte Cloning, Yokohama, Kanagawa 2300045, Japan

[4] RIKEN, Res Ctr Allergy & Immunol, Lab Dev Genet, Yokohama, Kanagawa 2300045, Japan

[5] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Lymphocyte Differentiat, Osaka 5650871, Japan

[6] Osaka Univ, Grad Sch Frontier Biosci, Osaka 5650871, Japan

[7] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Tsukuba, Ibaraki 3058566, Japan

来源：

IMMUNITY | 2013年 / 39卷 / 01期

关键词：

MURINE MEMORY; ANTIGEN; EXPRESSION; PATHWAY; MATURATION; IDENTITY; AFFINITY; PROMOTES; SURVIVAL; BLIMP-1;

D O I：

10.1016/j.immuni.2013.06.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Memory B cells are essential for generating rapid and robust secondary antibody responses. It has been thought that the unique cytoplasmic domain of IgG causes the prompt activation of antigen-experienced IgG memory B cells. To assess this model, we have generated a mouse containing IgG1 B cells that have never encountered antigen. We found that, upon challenge, antigen-experienced IgG1 memory B cells rapidly differentiated into plasma cells, whereas nonexperienced IgG1 B cells did not, suggesting the importance of the stimulation history. In addition, our results suggest that repression of the Bach2 transcription factor, which results from antigen experience, contributes to predisposition of IgG1 memory B cells to differentiate into plasma cells.

引用

页码：136 / 147

页数：12

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