Clathrin adaptors really adapt

被引：82

作者：

Kirchhausen, T ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Ctr Blood Res, Boston, MA 02115 USA

来源：

CELL | 2002年 / 109卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(02)00751-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Call (Collins et al., 2002) describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with the membrane and cytosolic tails of cargo proteins.

引用

页码：413 / 416

页数：4

共 20 条

[1] Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs) [J].

Boehm, M ;

Aguilar, RC ;

Bonifacino, JS .

EMBO JOURNAL, 2001, 20 (22) :6265-6276

[2] Adaptins - The final recount [J].

Boehm, M ;

Bonifacino, JS .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (10) :2907-2920

[3] A region from the medium chain adaptor subunit (μ) recognizes leucine- and tyrosine-based sorting signals [J].

Bremnes, T ;

Lauvrak, V ;

Lindqvist, B ;

Bakke, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) :8638-8645

[4] Molecular architecture and functional model of the endocytic AP2 complex [J].

Collins, BM ;

McCoy, AJ ;

Kent, HM ;

Evans, PR ;

Owen, DJ .

CELL, 2002, 109 (04) :523-535

[5] Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis [J].

Conner, SD ;

Schmid, SL .

JOURNAL OF CELL BIOLOGY, 2002, 156 (05) :921-929

[6] Essential role of phosphoinositide metabolism in synaptic vesicle recycling [J].

Cremona, O ;

Di Paolo, G ;

Wenk, MR ;

Lüthi, A ;

Kim, WT ;

Takei, K ;

Daniell, L ;

Nemoto, Y ;

Shears, SB ;

Flavell, RA ;

McCormick, DA ;

De Camilli, P .

CELL, 1999, 99 (02) :179-188

[7] Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits [J].

Gaidarov, I ;

Keen, JH .

JOURNAL OF CELL BIOLOGY, 1999, 146 (04) :755-764

[8] AP-2 recruitment to synaptotagmin stimulated by tyrosine-based endocytic motifs [J].

Haucke, V ;

De Camilli, P .

SCIENCE, 1999, 285 (5431) :1268-1271

[9] CLATHRIN-COATED VESICLES - ISOLATION, DISSOCIATION AND FACTOR-DEPENDENT REASSOCIATION OF CLATHRIN BASKETS [J].

KEEN, JH ;

WILLINGHAM, MC ;

PASTAN, IH .

CELL, 1979, 16 (02) :303-312

[10] Three ways to make a vesicle [J].

Kirchhausen, T .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :187-198

← 1 2 →