Redox- and pH-Controlled Mechanized Nanoparticles

被引：91

作者：

Khashab, Niveen M. ^{[3
]}

Trabolsi, Ali ^{[3
]}

Lau, Yuen A. ^{[1
,2
]}

Ambrogio, Michael W. ^{[3
]}

Friedman, Douglas C. ^{[3
]}

Khatib, Hussam A. ^{[3
]}

Zink, Jeffrey I. ^{[1
,2
]}

Stoddart, J. Fraser ^{[3
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 11期

基金：

美国国家科学基金会;

关键词：

Ferrocene; Nanoparticles; Cucurbit[7]uril; beta-Cyclodextrin; Redox chemistry; HOST-GUEST COMPLEXATION; BETA-CYCLODEXTRIN; FERROCENE DERIVATIVES; MESOPOROUS SILICA; INCLUSION COMPLEXATION; MOLECULAR RECOGNITION; BINDING INTERACTIONS; CUCURBITURIL; VIOLOGENS; DELIVERY;

D O I：

10.1002/ejoc.200801300

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of mechanized silica nanoparticles, which exploits the stability of the inclusion complexes formed between ferrocenedicarboxylic acid and both cucurbit[7]uril (CB7) and beta-cyclodextrin (beta-CD), are described. Mesoporous silica nanoparticles, capable of storing a payload of small molecules and releasing it following particular activation processes, have been designed and decorated with ferrocenecarboxylic acid stalks. The storage and release of the payload is controlled by the host-guest interaction between the ferrocene moiety (guest) and the ring moiety (CB7 or beta-CD). Ferrocene-based Mechanized NanoParticles (FMNPs) were efficiently prepared, loaded with Rhodamine dye, and then tested under different activation procedures. The systems operated successfully under redox control (oxidation of ferrocenedicarboxylic acid) in the presence of P-CD and under pH control (deprotonation of ferrocenedicarboxylic acid pH > 4) in the presence of CB7. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：1669 / 1673

页数：5

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