Players in the PARP-1 cell-death pathway: JNK1 joins the cast

被引：28

作者：

Alano, Conrad C.

Swanson, Raymond A.

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA

[2] Vet Affairs Med Ctr, San Francisco, CA 94121 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 06期

关键词：

D O I：

10.1016/j.tibs.2006.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) triggers a cell-death pathway in which mitochondria play an integral part, but it remains uncertain how PARP-1 activation in the nucleus is signaled to the mitochondria. A recent report by Xu and colleagues suggests that Jun kinase-1, a member of the mitogen-activated protein kinase family, might have a crucial role in this signaling pathway.

引用

页码：309 / 311

页数：3

共 25 条

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