Molecular characterization of attenuated Junin virus strains

被引：37

作者：

Albarino, CG

Ghiringhelli, PD

Posik, DM

Lozano, ME

Ambrosio, AM

Sanchez, A

Romanowski, V

机构：

[1] NATL UNIV LA PLATA,FAC CIENCIAS EXACTAS,INST BIOQUIM & BIOL MOL,DEPT CIENCIAS BIOL,RA-1900 LA PLATA,ARGENTINA

[2] UNIV NACL QUILMES,DEPT CIENCIA & TECNOL,RA-1876 BERNAL,ARGENTINA

[3] INST ESTUDIOS ENFERMEDADES VIRALES HUMANAS,RA-2700 PERGAMINO,ARGENTINA

[4] CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333

来源：

JOURNAL OF GENERAL VIROLOGY | 1997年 / 78卷

关键词：

D O I：

10.1099/0022-1317-78-7-1605

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.

引用

页码：1605 / 1610

页数：6

共 22 条

[1] SEQUENCING STUDIES OF PICHINDE ARENAVIRUS S-RNA INDICATE A NOVEL CODING STRATEGY, AN AMBISENSE VIRAL S-RNA
AUPERIN, DD
ROMANOWSKI, V
GALINSKI, M
BISHOP, DHL
[J]. JOURNAL OF VIROLOGY, 1984, 52 (03) : 897 - 904
[2] Oliveros virus: A novel arenavirus from Argentina
Bowen, MD
Peters, CJ
Mills, JN
Nichol, ST
[J]. VIROLOGY, 1996, 217 (01) : 362 - 366
[3] The phylogeny of new world (Tacaribe complex) arenaviruses
Bowen, MD
Peters, CJ
Nichol, ST
[J]. VIROLOGY, 1996, 219 (01) : 285 - 290
[4] CLEGG JCS, 1993, ARENAVIRIDAE, P175
[5] ATTENUATED MUTANTS OF VENEZUELAN EQUINE ENCEPHALITIS-VIRUS CONTAINING LETHAL MUTATIONS IN THE PE2 CLEAVAGE SIGNAL COMBINED WITH A 2ND-SITE SUPPRESSOR MUTATION IN E1
DAVIS, NL
BROWN, KW
GREENWALD, GF
ZAJAC, AJ
ZACNY, VL
SMITH, JF
JOHNSTON, RE
[J]. VIROLOGY, 1995, 212 (01) : 102 - 110
[6] GLYCOSYLATION AFFECTS CLEAVAGE OF AN H5N2 INFLUENZA-VIRUS HEMAGGLUTININ AND REGULATES VIRULENCE
DESHPANDE, KL
FRIED, VA
ANDO, M
WEBSTER, RG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (01) : 36 - 40
[7] NEUROATTENUATION OF AN AVIRULENT BUNYAVIRUS VARIANT MAPS TO THE L-RNA SEGMENT
ENDRES, MJ
GRIOT, C
GONZALEZSCARANO, F
NATHANSON, N
[J]. JOURNAL OF VIROLOGY, 1991, 65 (10) : 5465 - 5470
[8] Franze-Fernandez MT., 1993, ARENAVIRIDAE, P113, DOI DOI 10.1007/978-1-4615-3028-2_
[9] TACARIBE ARENAVIRUS RNA-SYNTHESIS INVITRO IS PRIMER DEPENDENT AND SUGGESTS AN UNUSUAL MODEL FOR THE INITIATION OF GENOME REPLICATION
GARCIN, D
KOLAKOFSKY, D
[J]. JOURNAL OF VIROLOGY, 1992, 66 (03) : 1370 - 1376
[10] MOLECULAR-ORGANIZATION OF JUNIN VIRUS-S RNA - COMPLETE NUCLEOTIDE-SEQUENCE, RELATIONSHIP WITH OTHER MEMBERS OF THE ARENAVIRIDAE AND UNUSUAL SECONDARY STRUCTURES
GHIRINGHELLI, PD
RIVERAPOMAR, RV
LOZANO, ME
GRAU, O
ROMANOWSKI, V
[J]. JOURNAL OF GENERAL VIROLOGY, 1991, 72 : 2129 - 2141

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