Anoikis - Cancer and the homeless cell

被引：154

作者：

Liotta, LA ^{[1
]}

Kohn, E ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

NATURE | 2004年 / 430卷 / 7003期

关键词：

D O I：

10.1038/430973a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A protein has been identified that enables cells to survive when dislodged from their substrate, and to migrate to new sites in the body. Such a mechanism might give cancer cells a significant advantage.

引用

页码：973 / 974

页数：2

共 11 条

[1] Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis [J].

Brader, S ;

Eccles, SA .

TUMORI JOURNAL, 2004, 90 (01) :2-8

[2]

Davies MA, 1998, CANCER RES, V58, P5285

[3] Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB [J].

Douma, S ;

van Laar, T ;

Zevenhoven, J ;

Meuwissen, R ;

van Garderen, E ;

Peeper, DS .

NATURE, 2004, 430 (7003) :1034-1040

[4]

ENDEL HG, 2004, NATURE, V428, P332

[5] Integrins and anoikis [J].

Frisch, SM ;

Ruoslahti, E .

CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (05) :701-706

[6] Trk receptors: Roles in neuronal signal transduction [J].

Huang, EJ ;

Reichardt, LF .

ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :609-642

[7] Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells [J].

Kim, H ;

Li, Q ;

Hempstead, BL ;

Madri, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (32) :33538-33546

[8] Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors [J].

Lawlor, ER ;

Scheel, C ;

Irving, J ;

Sorensen, PHB .

ONCOGENE, 2002, 21 (02) :307-318

[9] The microenvironment of the tumour-host interface [J].

Liotta, LA ;

Kohn, EC .

NATURE, 2001, 411 (6835) :375-379

[10] Activation of the protein kinase Akt PKB by the formation of E-cadherin-mediated cell-cell junctions - Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex [J].

Pece, S ;

Chiariello, M ;

Murga, C ;

Gutkind, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :19347-19351

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