Brain-derived neurotrophic factor, stress and depression: A minireview

被引：100

作者：

Yulug, Burak ^{[1
]}

Ozan, Erol ^{[2
]}

Goenuel, Ali Saffet ^{[3
]}

Kilic, Ertugrul ^{[4
]}

机构：

[1] Univ Bern, Dept Psychiat, Bern, Switzerland

[2] Ataturk Univ, Dept Psychiat, Erzurum, Turkey

[3] Univ Ege, Dept Psychiat, Izmir, Turkey

[4] Univ Yeditepe, Dept Physiol, Brain Res Lab, Istanbul, Turkey

来源：

BRAIN RESEARCH BULLETIN | 2009年 / 78卷 / 06期

关键词：

Depression; BDNF; Neuroprotection; FACTOR BDNF; HIPPOCAMPAL VOLUME; VAL66MET POLYMORPHISM; BIPOLAR DISORDER; MESSENGER-RNA; HUMAN-MEMORY; SERUM; SURVIVAL; DIFFERENTIATION; ASSOCIATION;

D O I：

10.1016/j.brainresbull.2008.12.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression are rapidly replicating. Considering the data that stress plays an important role by the development of depression which is characterized with prominent hippocampal cell death, as well as the well known neuroprotective effects of BDNF, we aimed to investigate the link between the BDNF, stress and depression. Thus we prepared a minireview in order to evaluate the neuroprotective role of BDNF by psychiatric disorders which are characterized with prominent neuronal cell death. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：267 / 269

页数：3

共 57 条

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The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study [J].