The Impact of Obesity on Risk Factors and Prevalence and Prognosis of Coronary Heart Disease-The Obesity Paradox

被引：181

作者：

De Schutter, Alban ^{[1
]}

Lavie, Carl J. ^{[1
,2
]}

Milani, Richard V. ^{[1
]}

机构：

[1] Univ Queensland, Sch Med, Ochsner Heart & Vasc Inst, Ochsner Clin Sch, New Orleans, LA 70121 USA

[2] Louisiana State Univ Syst, Dept Prevent Med, Pennington Biomed Res Ctr, Baton Rouge, LA USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2014年 / 56卷 / 04期

关键词：

Obesity; Obesity paradox; Coronary heart disease; BODY-MASS INDEX; OBSTRUCTIVE PULMONARY-DISEASE; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; TOTAL MORTALITY; ADIPOSE-TISSUE; UNITED-STATES; FAT; OUTCOMES;

D O I：

10.1016/j.pcad.2013.08.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Obesity is associated with a host of cardiovascular risk factors and its prevalence is rising rapidly. Despite strong evidence that obesity predisposes to the development and progression of coronary heart disease (CHD), numerous studies have shown an inverse relationship between various measures of obesity (most commonly body mass index) and outcomes in established CHD. In this article we review the evidence surrounding the "obesity paradox" in the secondary care of CHD patients and the CHD presentations where a paradox has been found. Finally we discuss the impact of cardiorespiratory fitness and a number of mechanisms which may offer potential explanations for this puzzling phenomenon. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：401 / 408

页数：8

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