Survivin is upregulated during liver regeneration in rats and humans and is associated with hepatocyte proliferation

被引：16

作者：

Baba, Hideo A. ^{[1
]}

Wohlschlaeger, Jeremias ^{[1
]}

Schmitz, Klaus J. ^{[1
]}

Nadalin, Silvio ^{[2
]}

Lang, Hauke ^{[2
]}

Benesch, Alexandra ^{[1
]}

Gu, Yanli ^{[2
]}

Biglarnia, Ali-R ^{[2
]}

Sotiropoulos, Georgios C. ^{[2
]}

Takeda, Atsushi

Takeda, Nobuakira ^{[3
]}

Lipinski, Karen von Wnuck ^{[4
]}

Levkau, Bodo ^{[4
]}

机构：

[1] Univ Duisburg Essen, Inst Pathol & Neuropathol, D-45122 Essen, Germany

[2] Univ Duisburg Essen, Dept Gen Visceral & Transplantat Surg, D-45122 Essen, Germany

[3] Jikei Univ, Dept Internal Med, Tokyo, Japan

[4] Univ Duisburg Essen, Inst Pathophysiol, D-45122 Essen, Germany

来源：

LIVER INTERNATIONAL | 2009年 / 29卷 / 04期

关键词：

apoptosis; liver regeneration; living donor liver transplantation; proliferation; survivin; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; PARTIAL-HEPATECTOMY; CELL-DIVISION; APOPTOSIS; EXPRESSION; PATHWAYS; INHIBITOR; PATHOLOGY; PROTEIN; MITOSIS;

D O I：

10.1111/j.1478-3231.2008.01911.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Survivin regulates cell division and inhibits apoptosis. Liver regeneration is a complex process involving both proliferation and apoptosis. The role of survivin is not well elucidated and no data exist in humans. Seventy per cent liver resection was used to investigate liver regeneration in rats. Survivin was identified by means of reverse transcriptase polymerase chain reaction, Western blotting and immunohistochemistry. Proliferation and apoptosis were quantified. Liver biopsies from 33 patients who underwent living donor liver transplantation were used to study survivin immuno-expression, proliferation and apoptosis within the first 17 days after transplantation. Seven healthy donors served as controls. Survivin transcript and protein were significantly upregulated in rat hepatocytes after 24-72 h during regeneration and showed a significant correlation with proliferation but not with apoptosis. In humans, survivin was nearly absent in donor and reperfused liver tissue but increased significantly 5-7 days after transplantation and correlated with proliferation but not with apoptosis. Survivin is upregulated in human and rodent liver regeneration and correlates with proliferation, suggesting an association of survivin and cell division.

引用

页码：585 / 592

页数：8

共 27 条

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Molecular circuits of apoptosis regulation and cell division control: The survivin paradigm [J].