Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen

被引:45
作者
McElrath, MJ
Corey, L
Greenberg, PD
Matthews, TJ
Montefiori, DC
Rowen, L
Hood, L
Mullins, JI
机构
[1] UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195
[2] UNIV WASHINGTON,SCH MED,DEPT LAB MED,SEATTLE,WA 98195
[3] UNIV WASHINGTON,SCH MED,DEPT IMMUNOL,SEATTLE,WA 98195
[4] UNIV WASHINGTON,SCH MED,DEPT MOLEC BIOTECHNOL,SEATTLE,WA 98195
[5] UNIV WASHINGTON,SCH MED,DEPT MICROBIOL,SEATTLE,WA 98195
[6] DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710
关键词
D O I
10.1073/pnas.93.9.3972
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether prior HIV-1 immunity can alter the subsequent course of HIV-1 infection. We investigated these issues in the context of a volunteer who received six HIV-lwr envelope immunizations and 10 weeks thereafter acquired HIV-1 infection through a high-risk sexual exposure. In contrast to nonvaccinated acutely infected individuals, anamnestic HIV-1-specific B- and T-cell responses appeared within 3 weeks in this individual, and neutralizing antibody preceded CD8(+) cytoxic responses. Despite an asymptomatic course and an initial low level of detectable infectious virus, a progressive CD4(+) cell decline and dysfunction occurred within 2 years. Although vaccination elicited immunity to HIV-1 envelope, which was recalled upon HIV-1 exposure, it was insufficient to prevent infection and subsequent immunodeficiency.
引用
收藏
页码:3972 / 3977
页数:6
相关论文
共 39 条
[1]   REDUCED VIRUS LOAD IN RHESUS MACAQUES IMMUNIZED WITH RECOMBINANT GP160 AND CHALLENGED WITH SIMIAN IMMUNODEFICIENCY VIRUS [J].
AHMAD, S ;
LOHMAN, B ;
MARTHAS, M ;
GIAVEDONI, L ;
ELAMAD, Z ;
HAIGWOOD, NL ;
SCANDELLA, CJ ;
GARDNER, MB ;
LUCIW, PA ;
YILMA, T .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (02) :195-204
[2]  
BELSHE RB, 1994, JAMA-J AM MED ASSOC, V272, P431, DOI 10.1001/jama.272.6.431b
[3]   SAFETY AND IMMUNOGENICITY OF A FULLY GLYCOSYLATED RECOMBINANT GP160 HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VACCINE IN SUBJECTS AT LOW-RISK OF INFECTION [J].
BELSHE, RB ;
CLEMENTS, ML ;
DOLIN, R ;
GRAHAM, BS ;
MCELRATH, J ;
GORSE, GJ ;
SCHWARTZ, D ;
KEEFER, MC ;
WRIGHT, P ;
COREY, L ;
BOLOGNESI, DP ;
MATTHEWS, TJ ;
STABLEIN, DM ;
OBRIEN, FS ;
EIBL, M ;
DORNER, F ;
KOFF, W .
JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (06) :1387-1395
[4]   PROTECTION OF CHIMPANZEES FROM INFECTION BY HIV-1 AFTER VACCINATION WITH RECOMBINANT GLYCOPROTEIN GP120 BUT NOT GP160 [J].
BERMAN, PW ;
GREGORY, TJ ;
RIDDLE, L ;
NAKAMURA, GR ;
CHAMPE, MA ;
PORTER, JP ;
WURM, FM ;
HERSHBERG, RD ;
COBB, EK ;
EICHBERG, JW .
NATURE, 1990, 345 (6276) :622-625
[5]   MACROPHAGE-TROPIC HUMAN-IMMUNODEFICIENCY-VIRUS ISOLATES FROM DIFFERENT PATIENTS EXHIBIT UNUSUAL V3 ENVELOPE SEQUENCE HOMOGENEITY IN COMPARISON WITH T-CELL-TROPIC ISOLATES - DEFINITION OF CRITICAL AMINO-ACIDS INVOLVED IN CELL TROPISM [J].
CHESEBRO, B ;
WEHRLY, K ;
NISHIO, J ;
PERRYMAN, S .
JOURNAL OF VIROLOGY, 1992, 66 (11) :6547-6554
[6]   PLASMA VIREMIA IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTION [J].
COOMBS, RW ;
COLLIER, AC ;
ALLAIN, JP ;
NIKORA, B ;
LEUTHER, M ;
GJERSET, GF ;
COREY, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1626-1631
[7]   ENHANCED IMMUNITY TO HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) ENVELOPE ELICITED BY A COMBINED VACCINE REGIMEN CONSISTING OF PRIMING WITH A VACCINIA RECOMBINANT EXPRESSING HIV ENVELOPE AND BOOSTING WITH GP160-PROTEIN [J].
COONEY, EL ;
MCELRATH, MJ ;
COREY, L ;
HU, SL ;
COLLIER, AC ;
ARDITTI, D ;
HOFFMAN, M ;
COOMBS, RW ;
SMITH, GE ;
GREENBERG, PD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1882-1886
[8]   SAFETY OF AND IMMUNOLOGICAL RESPONSE TO A RECOMBINANT VACCINIA VIRUS-VACCINE EXPRESSING HIV ENVELOPE GLYCOPROTEIN [J].
COONEY, EL ;
COLLIER, AC ;
GREENBERG, PD ;
COOMBS, RW ;
ZARLING, J ;
ARDITTI, DE ;
HOFFMAN, MC ;
HU, SL ;
COREY, L .
LANCET, 1991, 337 (8741) :567-572
[9]   PROTECTIVE EFFECTS OF A LIVE ATTENUATED SIV VACCINE WITH A DELETION IN THE NEF GENE [J].
DANIEL, MD ;
KIRCHHOFF, F ;
CZAJAK, SC ;
SEHGAL, PK ;
DESROSIERS, RC .
SCIENCE, 1992, 258 (5090) :1938-1941
[10]   GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES [J].
DELWART, EL ;
SHPAER, EG ;
LOUWAGIE, J ;
MCCUTCHAN, FE ;
GREZ, M ;
RUBSAMENWAIGMANN, H ;
MULLINS, JI .
SCIENCE, 1993, 262 (5137) :1257-1261