TreeFam:: a curated database of phylogenetic trees of animal gene families

被引:393
作者
Li, Heng
Coghlan, Avril
Ruan, Jue
Coin, Lachlan James
Heriche, Jean-Karim
Osmotherly, Lara
Li, Ruiqiang
Liu, Tao
Zhang, Zhang
Bolund, Lars
Wong, Gane Ka-Shu
Zheng, Weimou
Dehal, Paramvir
Wang, Jun
Durbin, Richard
机构
[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[2] Chinese Acad Sci, Beijing Inst Gen, Beijing Gen Inst, Beijing 101300, Peoples R China
[3] Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
[4] Univ Aarhus, Inst Human Genet, DK-8000 Aarhus C, Denmark
[5] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark
[6] Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
[7] Univ Washington, Dept Med, Genome Ctr, Seattle, WA 98195 USA
[8] Joint Genome Inst, Evolutionary Gen Dept, Dept Energy, Walnut Creek, CA USA
[9] Lawrence Berkeley Lab, Walnut Creek, CA USA
关键词
D O I
10.1093/nar/gkj118
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
TreeFam is a database of phylogenetic trees of gene families found in animals. It aims to develop a curated resource that presents the accurate evolutionary history of all animal gene families, as well as reliable ortholog and paralog assignments. Curated families are being added progressively, based on seed alignments and trees in a similar fashion to Pfam. Release 1.1 of TreeFam contains curated trees for 690 families 25 and automatically generated trees for another 11 646 families. These represent over 128 000 genes from nine fully sequenced animal genomes and over 45 000 other animal proteins from UniProt; similar to 40 - 85% of proteins encoded in the fully sequenced animal genomes are included in TreeFam. TreeFam is freely available at http://www.treefam.org and http://treefam.genomics.org.cn.
引用
收藏
页码:D572 / D580
页数:9
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