Colistin efficacy in an experimental model of Acinetobacter baumannii endocarditis

被引：26

作者：

Rodríguez-Hernández, MJ

Jiménez-Mejias, ME

Pichardo, C

Cuberos, L

García-Curiel, A

Pachón, J

机构：

[1] Univ Hosp Virgen Rocio, Infect Dis Serv, Seville 41013, Spain

[2] Univ Hosp Virgen Rocio, Serv Emergency & Crit Care, Seville 41013, Spain

[3] Univ Hosp Virgen Rocio, Microbiol Serv, Seville 41013, Spain

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 06期

关键词：

Acinetobacter baumannii; bacteraemia; colistin; endocarditis;

D O I：

10.1111/j.1469-0691.2004.00910.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vivo activity of colistin was evaluated in an experimental rabbit model of Acinetobacter baumannii endocarditis with a strain susceptible to colistin and intermediate to imipenem. Compared to a control group, colistin was effective (p < 0.05) in bacterial clearance from blood and in the sterilisation of blood cultures, but was not effective in clearing A. baumannii from vegetations. Thus, although colistin may be effective in treating bacteraemia caused by susceptible strains of A. baumannii, it may not be a suitable treatment for endocarditis, perhaps because of poor penetration into vegetations and a low C-max/MIC ratio in tissue.

引用

收藏

页码：581 / 584

页数：5

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