Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines

被引：152

作者：

Hacohen, Nir ^{[1
,3
]}

Fritsch, Edward F. ^{[1
,2
]}

Carter, Todd A. ^{[1
]}

Lander, Eric S. ^{[1
]}

Wu, Catherine J. ^{[2
,4
]}

机构：

[1] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Canc Vaccine Ctr, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Dept Med, Div Allergy Immunol & Rheumatol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2013年 / 1卷 / 01期

关键词：

CYTOLYTIC T-LYMPHOCYTES; TUMOR-SPECIFIC ANTIGENS; POINT MUTATION; HUMAN-MELANOMA; HIGH-FREQUENCY; CELL EPITOPES; VACCINATION; ANTIBODY; PREDICTION; REGRESSION;

D O I：

10.1158/2326-6066.CIR-13-0022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite years of preclinical efforts and hundreds of clinical studies, therapeutic cancer vaccines with the routine ability to limit or eliminate tumor growth in humans have been elusive. With advances in genome sequencing, it is now possible to identify a new class of tumor-specific antigens derived from mutated proteins that are present only in the tumor. These "neoantigens" should provide highly specific targets for antitumor immunity. Although many challenges remain in producing and testing neoantigen-based vaccines customized for each patient, a neoantigen vaccine offers a promising new approach to induce highly focused antitumor T cells aimed at eradicating cancer cells. (C)2013 AACR.

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页码：11 / 15

页数：5

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