Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake

被引：37

作者：

Callado, LF ^{[1
]}

Hopwood, SE ^{[1
]}

Hancock, PJ ^{[1
]}

Stamford, JA ^{[1
]}

机构：

[1] Royal London Hosp, St Bartholomews & Royal London Sch Med & Dent, Acad Dept Anaesthesia & Intens Care, Neurotransmiss Lab, London E1 1BB, England

来源：

NEUROREPORT | 2000年 / 11卷 / 01期

关键词：

dizocilpine; dopamine; dorsal raphe nucleus; locus coeruleus; noradrenaline; nucleus accumbens; serotonin; voltammetry;

D O I：

10.1097/00001756-200001170-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we examined the actions of the NMDA antagonist dizocilpine (MK801) on electrically evoked release and uptake of noradrenaline (NA) in the locus coeruleus (LC), serotonin (5-HT) in the dorsal raphe nucleus (DRN) and dopamine (DA) in the nucleus accumbens (NAc), measured by fast cyclic voltammetry (FCV) in rat brain slices. Dizocilpine (10 mu M) significantly increased NA (to 248 +/- 15%) and 5-HT release (to 184+/-29%) and slowed monoamine uptake in the LC (t(1/2)=853+/-129%) and the DRN (t(1/2)=387+/-70%), respectively. However, dizocilpine had no effect on DA release or uptake in NAc. Actions on monoamines are thus likely and should be considered in the interpretation of data regarding dizocilpine. NeuroReport 11:173-176 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：173 / 176

页数：4

共 27 条

[1] Dizocilpine (MK-801) and tetrodotoxin influence accumbal dopamine release evoked by intrapallidal morphine [J].