Nutrient control of TORC1, a cell-cycle regulator

被引：121

作者：

Wang, Xuemin ^{[1
]}

Proud, Christopher G. ^{[1
]}

机构：

[1] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

TRENDS IN CELL BIOLOGY | 2009年 / 19卷 / 06期

关键词：

AMINO-ACID SUFFICIENCY; MAMMALIAN TARGET; S6; KINASE; PROTEIN-SYNTHESIS; DEPENDENT MANNER; MESSENGER-RNA; TRANSLATIONAL CONTROL; SIGNALING PATHWAY; D1; EXPRESSION; RAG GTPASES;

D O I：

10.1016/j.tcb.2009.03.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in controlling cell functions (including protein synthesis, cell growth and cell proliferation) and is implicated in numerous human diseases. Mammalian TOR complex 1 (mTORC1) signalling is activated by hormones and growth factors, and is also stimulated by intracellular amino acids. Recent research has provided important new insight into the poorly understood mechanism by which amino acids activate mTORC1 signalling, showing that the protein kinase MAP4K3 and Rag GTPases have important roles in this. mTORC1 is known to control the G1/S transition of the cell cycle: new data show that (m)TORC1 also controls G2/M progression in yeast and mammals, albeit in contrasting ways.

引用

页码：260 / 267

页数：8

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