Challenges to curing primary brain tumours

被引：732

作者：

Aldape, Kenneth ^{[1
]}

Brindle, Kevin M. ^{[2
]}

Chesler, Louis ^{[3
]}

Chopra, Rajesh ^{[3
]}

Gajjar, Amar ^{[4
]}

Gilbert, Mark R. ^{[5
]}

Gottardo, Nicholas ^{[6
]}

Gutmann, David H. ^{[7
]}

Hargrave, Darren ^{[8
]}

Holland, Eric C. ^{[9
]}

Jones, David T. W. ^{[10
]}

Joyce, Johanna A. ^{[11
]}

Kearns, Pamela ^{[12
]}

Kieran, Mark W. ^{[13
,14
,15
]}

Mellinghoff, Ingo K. ^{[16
,17
]}

Merchant, Melinda ^{[18
]}

Pfister, Stefan M. ^{[19
]}

Pollard, Steven M. ^{[20
,21
]}

Ramaswamy, Vijay ^{[22
]}

Rich, Jeremy N. ^{[23
]}

Robinson, Giles W. ^{[4
]}

Rowitch, David H. ^{[24
,25
]}

Sampson, John H. ^{[26
]}

Taylor, Michael D. ^{[27
,28
]}

Workman, Paul ^{[3
]}

Gilbertson, Richard J. ^{[2
,29
,30
,31
]}

机构：

[1] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada

[2] CRUK Cambridge Inst, Li Ka Shing Ctr, Cambridge, England

[3] Inst Canc Res, London, England

[4] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] NCI, Ctr Canc Res, Bethesda, MD 20892 USA

[6] Telethon Kids Inst, Subiaco, WA, Australia

[7] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[8] Great Ormond St Hosp Sick Children, London, England

[9] Fred Hutchinson Canc Res Ctr, Human Biol Div, 1124 Columbia St, Seattle, WA 98104 USA

[10] NCT Heidelberg, Hopp Childrens Canc Ctr, Pediat Glioma Res Grp, Heidelberg, Germany

[11] Univ Lausanne, Ludwig Inst Canc Res, Lausanne, Switzerland

[12] Univ Birmingham, Inst Canc & Genom Sci, Canc Res UK Clin Trials Unit, Birmingham, W Midlands, England

[13] Dana Farber Boston Childrens Canc, Boston, MA USA

[14] Blood Disorders Ctr, Boston, MA USA

[15] Harvard Med Sch, Boston, MA 02115 USA

[16] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[17] Mem Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 10021 USA

[18] AstraZeneca IMED Biotech Unit, Oncol, Boston, MA USA

[19] NCT Heidelberg, Hopp Childrens Canc Ctr, Div Pediat Oncol, Heidelberg, Germany

[20] Univ Edinburgh, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland

[21] Univ Edinburgh, Ctr Regenerat Med, Med Res Council, Edinburgh, Midlothian, Scotland

[22] Hosp Sick Children, Dept Paediat, Toronto, ON, Canada

[23] Univ Calif San Diego, Dept Med, Div Regenerat Med, San Diego, CA 92103 USA

[24] Univ Cambridge, Dept Paediat, Cambridge, England

[25] Wellcome Trust MRC Stem Cell Inst, Cambridge, England

[26] Duke Canc Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC USA

[27] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada

[28] Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada

[29] Univ Cambridge, CRUK Cambridge Inst, Cambridge, England

[30] Univ Cambridge, Dept Oncol, Cambridge, England

[31] Cambridge Biomed Campus, Hutchison MRC Res Ctr, Cambridge, England

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2019年 / 16卷 / 08期

关键词：

CENTRAL-NERVOUS-SYSTEM; LOW-GRADE GLIOMA; STEM-CELLS; MOLECULAR CLASSIFICATION; DRIVER MUTATIONS; ADULT SURVIVORS; CANCER; GLIOBLASTOMA; CHEMOTHERAPY; MEDULLOBLASTOMA;

D O I：

10.1038/s41571-019-0177-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

引用

页码：509 / 520

页数：12

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