Probes for imidazoline binding sites:: Synthesis and evaluation of a selective, irreversible I2 ligand

被引：15

作者：

Coates, PA

Grundt, P

Robinson, ESJ

Nutt, DJ

Tyacke, R

Hudson, AL

Lewis, JW

Husbands, SM

机构：

[1] Univ Bristol, Sch Chem, Bristol, Avon, England

[2] Univ Bristol, Dept Psychopharmacol, Bristol, Avon, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00062-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An irreversible ligand (7) has been prepared based on the selective I-2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I-2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I-2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：605 / 607

页数：3

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