Association of mutations in grlA and gyrA topoisomerase genes with resistance to ciprofloxacin in epidemic and sporadic isolates of methicillin-resistant Staphylococcus aureus

被引：19

作者：

Deplano, A ^{[1
]}

Zekhnini, A ^{[1
]}

Allali, N ^{[1
]}

Couturier, M ^{[1
]}

Struelens, MJ ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,DEPT BIOL MOL,B-1640 RHODE ST GENESE,BELGIUM

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 09期

关键词：

D O I：

10.1128/AAC.41.9.2023

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The types of topoisomerase alterations in genomically diverse epidemic and sporadic strains of methicillin-and fluoroquinolone-resistant Staphylococcus aureus isolated from European hospitals between 1984 and 1994 were characterized. Convergent dual mutations in gyrA (codon 83, 84, or 88) and grlA (codon 79 and/or 80) were found in all strains exhibiting high-level resistance to ciprofloxacin (MIG, 16 to greater than or equal to 128 mu g/ml). In some epidemic strains, the resistant phenotype and genotype appeared in the 1990s and persisted thereafter.

引用

页码：2023 / 2025

页数：3

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