Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3

被引：232

作者：

Maestro, B

Molero, S

Bajo, S

Dávila, N

Calle, C ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol, E-28040 Madrid, Spain

[2] Hosp Puerta de Hierro, Serv Biochem, Madrid 28040, Spain

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2002年 / 20卷 / 03期

关键词：

1,25-dihydroxyvitamin D-3; human insulin receptor gene; transcriptional induction; glucose oxidation; wortmannin effect;

D O I：

10.1002/cbf.951

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment with 10(-8) m 1,25-dihydroxyvitamin D-3 for 24 h causes transcriptional activation of the human insulin receptor gene in U-937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, causes a greater inhibition of insulin-stimulated glucose oxidation in 1,25-dihydroxyvitamin D-3-treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3-kinase activity by 1,25-dihydroxyvitamin D-3, which could mediate, at least in part, the potentiation of the insulin response. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

收藏

页码：227 / 232

页数：6

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