Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy

被引：62

作者：

Jansen, Jacobus F. A.

Aldenkamp, Albert P.

Majoie, H. J. Marian

Reijs, Rianne P.

de Krom, Marc C. T. F. M.

Hofman, Paul A. M.

Kooi, M. Eline

Nicolay, Klaas

Backes, Walter H.

机构：

[1] Eindhoven Univ Technol, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

[2] Maastricht Univ Hosp, Dept Radiol, Maastricht, Netherlands

[3] Maastricht Univ Hosp, Dept Neurol, Maastricht, Netherlands

[4] Epilepsy Ctr Kempenhaeghe, Heeze, Netherlands

来源：

EPILEPSY & BEHAVIOR | 2006年 / 9卷 / 01期

关键词：

epilepsy; topiramate; cognition; language; neuropsychology; functional magnetic resonance imaging;

D O I：

10.1016/j.yebeh.2006.05.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：181 / 185

页数：5

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