Evolutionally conserved plant homologue of the Bax Inhibitor-1 (BI-1) gene capable of suppressing Bax-induced cell death in yeast

被引：124

作者：

Kawai, M

Pan, L

Reed, JC

Uchimiya, H ^{[1
]}

机构：

[1] Japan Atom Energy Res Inst, Adv Sci Res Ctr, Takasaki, Gumma 3701292, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[3] Burnham Inst, La Jolla, CA 92037 USA

来源：

FEBS LETTERS | 1999年 / 464卷 / 03期

关键词：

apoptosis; Bax; Bax Inhibitor; programmed cell death; Oryza;

D O I：

10.1016/S0014-5793(99)01695-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plant homologue of Bax Inhibitor-1, a gene described to suppress the cell death induced by Bax gene expression in yeast, was isolated from Oryza sativa L. (rice) and Arabidopsis. The amino acid sequence of the predicted protein was well conserved in both animal and plant (45% in amino acids) and contained six or seven membrane-spanning segments. Northern blot analysis showed that OsBI-1 transcripts were present in all tissues examined. The OsBI-1 cDNA suppressed cell death induced by mammalian Bax in yeast, suggesting functional conservation of this BI-I homologue in the plant kingdom. (C) 1999 Federation of European Biochemical Societies.

引用

页码：143 / 147

页数：5

共 24 条

[1] Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae [J].