Differential ER exit in yeast and mammalian cells

被引:39
作者
Watanabe, R [1 ]
Riezman, H [1 ]
机构
[1] Univ Geneva, CH-1211 Geneva 4, Switzerland
关键词
D O I
10.1016/j.ceb.2004.06.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The coat complex COPII forms vesicles at the endoplasmic reticulum to transport a variety of cargo proteins to the Golgi structure. Recent biochemical and structural studies reveal the molecular mechanism of cargo protein recognition by CON components. Furthermore, there are at least two distinct ER-to-Golgi transport carrier structures carrying different cargo proteins in yeast and mammalian cells, suggesting several distinct mechanisms for the concentration, selection and exit of cargo proteins from the ER. It will be essential to follow the dynamics of transitional ER sites and cargo protein concentration within the ER in order to understand how these transport processes occur in living cells.
引用
收藏
页码:350 / 355
页数:6
相关论文
共 31 条
[1]   ER export: public transportation by the COPII coach [J].
Antonny, B ;
Schekman, R .
CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (04) :438-443
[2]   Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast [J].
Bagnat, M ;
Keränen, S ;
Shevchenko, A ;
Shevchenko, A ;
Simons, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3254-3259
[3]   Signals for COPII-dependent export from the ER: what's the ticket out? [J].
Barlowe, C .
TRENDS IN CELL BIOLOGY, 2003, 13 (06) :295-300
[4]   Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles [J].
Belden, WJ ;
Barlowe, C .
SCIENCE, 2001, 294 (5546) :1528-1531
[5]   De novo formation of transitional ER sites and Golgi structures in Pichia pastoris [J].
Bevis, BJ ;
Hammond, AT ;
Reinke, CA ;
Glick, BS .
NATURE CELL BIOLOGY, 2002, 4 (10) :750-756
[6]   The mechanisms of vesicle budding and fusion [J].
Bonifacino, JS ;
Glick, BS .
CELL, 2004, 116 (02) :153-166
[7]   Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi [J].
Caldwell, SR ;
Hill, KJ ;
Cooper, AA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :23296-23303
[8]   Involvement of the endoplasmic reticulum in peroxisome formation [J].
Geuze, HJ ;
Murk, JL ;
Stroobants, AK ;
Griffith, JM ;
Kleijmeer, MJ ;
Koster, AJ ;
Verkleij, AJ ;
Distel, B ;
Tabak, HF .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (07) :2900-2907
[9]   Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with sar1 [J].
Giraudo, CG ;
Maccioni, HJF .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (09) :3753-3766
[10]   An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport [J].
Haynes, CM ;
Caldwell, S ;
Cooper, AA .
JOURNAL OF CELL BIOLOGY, 2002, 158 (01) :91-101