共 31 条
Differential ER exit in yeast and mammalian cells
被引:39
作者:

Watanabe, R
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机构:
Univ Geneva, CH-1211 Geneva 4, Switzerland Univ Geneva, CH-1211 Geneva 4, Switzerland

Riezman, H
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h-index: 0
机构:
Univ Geneva, CH-1211 Geneva 4, Switzerland Univ Geneva, CH-1211 Geneva 4, Switzerland
机构:
[1] Univ Geneva, CH-1211 Geneva 4, Switzerland
关键词:
D O I:
10.1016/j.ceb.2004.06.010
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The coat complex COPII forms vesicles at the endoplasmic reticulum to transport a variety of cargo proteins to the Golgi structure. Recent biochemical and structural studies reveal the molecular mechanism of cargo protein recognition by CON components. Furthermore, there are at least two distinct ER-to-Golgi transport carrier structures carrying different cargo proteins in yeast and mammalian cells, suggesting several distinct mechanisms for the concentration, selection and exit of cargo proteins from the ER. It will be essential to follow the dynamics of transitional ER sites and cargo protein concentration within the ER in order to understand how these transport processes occur in living cells.
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页码:350 / 355
页数:6
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