Design of acid - Base catalysis for the asymmetric direct aidol reaction

被引：388

作者：

Saito, S ^{[1
]}

Yamamoto, H

机构：

[1] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Grad Sch Sci, Nagoya, Aichi 4648602, Japan

[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar030064p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Proper design of acid-base catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction during the development of diamine-Bronsted acid types of catalyst. In this study, two principal approaches have been implemented to create a new type of catalysis and high catalytic efficiency: one is the creation of a highly viable acidic function within acid-base catalysts; the other is the creation of rather complicated but more cooperatively arranged hydrogen-bond networks that would be expected to stabilize a transition state, thereby promoting new reactivity and selectivity.

引用

页码：570 / 579

页数：10

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