5-HT2A receptor gene polymorphism and eating disorders

被引：61

作者：

Ricca, V

Nacmias, B

Cellini, E

Di Bernardo, M

Rotella, CM

Sorbi, S

机构：

[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy

[2] Univ Florence, Dept Pathophysiol, Unit Endocrinol, I-50134 Florence, Italy

来源：

NEUROSCIENCE LETTERS | 2002年 / 323卷 / 02期

关键词：

binge eating disorder; anorexia nervosa; bulimia nervosa; 5-HT2A polymorphism;

D O I：

10.1016/S0304-3940(02)00088-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have reported a genetic association between the -1438 G/A polymorphism within the promoter region of the 5-HT2A receptor gene and eating disorders (ED), with conflicting results. To clarify the role of the -1438 G/A polymorphism in different ED categories we have analyzed the genotype and allele frequency distribution in 54 Italian patients with Binge ED (BED) compared to 132 obese non-BED subjects. No significant differences were found between obese BED and obese non-BED individuals, suggesting that this polymorphism does not genetically distinguish these two phenotypes. Moreover, the evaluation of 148 patients with anorexia nervosa and 86 patients with bulimia nervosa revealed an association of the A allele with both these disorders. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

共 20 条

[1] Adjusting for multiple testing when reporting research results: The Bonferroni vs Holm methods [J].