A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran.

被引：68

作者：

Twyman, LJ ^{[1
]}

Allsop, D

机构：

[1] Univ Lancaster, Sch Phys & Chem, Lancaster LA1 4YQ, England

[2] Univ Lancaster, Dept Sci Biol, Lancaster LA1 4YQ, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 52期

关键词：

benzofurans; heterocyclic; intramolecular Wittig reaction; beta-amyloid; Alzheimer's disease;

D O I：

10.1016/S0040-4039(99)02030-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and convenient synthesis of 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]- benzofuran, an inhibitor of the aggregation of beta-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described. (C) 1999 Elsevier Science Ltd. Ali rights reserved.

引用

页码：9383 / 9384

页数：2

共 8 条

[1] Fibrillogenesis of β-amyloid [J].

Allsop, D ;

Howlett, D ;

Christie, G ;

Karran, E .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1998, 26 (03) :459-463

[2]

ARCADI A, 1986, SYNTHESIS-STUTTGART, V9, P449

[3]

Brenner LM, 1997, United States Patent, Patent No. [4,001,426, 4001426]

[4] AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].

HARDY, J ;

ALLSOP, D .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388

[5]

HERCOUET A, 1979, TETRAHEDRON LETT, V23, P2145

[6] Inhibition of fibril formation in β-amyloid peptide by a novel series of benzofurans [J].

Howlett, DR ;

Perry, AE ;

Godfrey, F ;

Swatton, JE ;

Jennings, KH ;

Spitzfaden, C ;

Wadsworth, H ;

Wood, SJ ;

Markwell, RE .

BIOCHEMICAL JOURNAL, 1999, 340 :283-289

[7]

HOWLETT DR, 1999, NEUROBIOLOGY ALZHEIM, P9

[8] Protein precipitation: a common etiology in neurodegenerative disorders? [J].

Kakizuka, A .

TRENDS IN GENETICS, 1998, 14 (10) :396-402

← 1 →