Hip fracture prevention with a multifactorial educational program in elderly community-dwelling Finnish women

被引:24
作者
Pekkarinen, T. [1 ]
Loyttyniemi, E. [2 ]
Valimaki, M. [3 ]
机构
[1] Univ Helsinki, Cent Hosp, Peijas Hosp, Div Endocrinol,Dept Med, FI-00029 Hus Vantaa, Finland
[2] Turku Univ, Dept Stat, FI-20014 Turku, Finland
[3] Univ Helsinki, Cent Hosp, Dept Med, Div Endocrinol, FI-00029 Hus Helsinki, Finland
关键词
Controlled trial; Hip fracture; Non-pharmacological; Postmenopausal women; Prevention; BONE-MINERAL DENSITY; RISK-FACTORS; OSTEOPOROTIC FRACTURES; PHYSICAL-ACTIVITY; OLDER; MORTALITY; ADHERENCE; CALCIUM; INTERVENTIONS; METAANALYSIS;
D O I
10.1007/s00198-013-2381-y
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Guidelines suggest identification of women at fracture risk by bone density measurement and subsequently pharmacotherapy. However, most women who sustain a hip fracture do not have osteoporosis in terms of bone density. The present non-pharmacological intervention among elderly women unselected for osteoporosis reduced hip fracture risk by 55 % providing an alternative approach to fracture prevention. Introduction Hip fractures are expensive for society and cause disability for those who sustain them. We studied whether a multifactorial non-pharmacological prevention program reduces hip fracture risk in elderly women. Methods A controlled trial concerning 60- to 70-year-old community-dwelling Finnish women was undertaken. A random sample was drawn from the Population Information System and assigned into the intervention group (IG) and control group (CG). Of the 2,547 women who were invited to the IG, 1,004 (39 %) and of the 2,120 invited to the CG, 1,174 (55%) participated. The IG participated in a fracture prevention program for 1 week at a rehabilitation center followed by review days twice. The CG received no intervention. During the 10-year follow-up, both groups participated in survey questionnaire by mail. Outcome of interest was occurrence of hip fractures and changes in bone-health-related lifestyle. Results During the follow-up, 12 (1.2 %) women in the IG and 29 (2.5 %) in the CG sustained a hip fracture (P=0.039). The determinants of hip fractures by stepwise logistic regression were baseline smoking (odds ratio (OR) 4.32 (95 % confidence interval [CI] 2.14-8.71), age OR 1.15/year (95 % CI 1.03-1.28), fall history OR 2.7 (95 % CI 1.24-5.9), stroke history OR 2.99 (95 % CI 1.19-7.54) and participating in this program OR 0.45 (95 % CI 0.22-0.93). Starting vitamin D and calcium supplement use was more common in the IG compared with the CG. Conclusions The results suggest that this non-pharmacological fracture prevention program may reduce the risk of hip fractures in elderly Finnish women.
引用
收藏
页码:2983 / 2992
页数:10
相关论文
共 48 条
[1]
Excess mortality following hip fracture: a systematic epidemiological review [J].
Abrahamsen, B. ;
van Staa, T. ;
Ariely, R. ;
Olson, M. ;
Cooper, C. .
OSTEOPOROSIS INTERNATIONAL, 2009, 20 (10) :1633-1650
[2]
Beard C. Mary, 1994, Annals of Epidemiology, V4, P398
[3]
RESPONSE BIAS IN THE HONOLULU HEART PROGRAM [J].
BENFANTE, R ;
REED, D ;
MACLEAN, C ;
KAGAN, A .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (06) :1088-1100
[4]
A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention [J].
Bischoff-Ferrari, Heike A. ;
Willett, Walter C. ;
Orav, Endel J. ;
Lips, Paul ;
Meunier, Pierre J. ;
Lyons, Ronan A. ;
Flicker, Leon ;
Wark, John ;
Jackson, Rebecca D. ;
Cauley, Jane A. ;
Meyer, Haakon E. ;
Pfeifer, Michael ;
Sanders, Kerrie M. ;
Stahelin, Hannes B. ;
Theiler, Robert ;
Dawson-Hughes, Bess .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (01) :40-49
[5]
MORTALITY AND CANCER RATES IN NONRESPONDENTS TO A PROSPECTIVE-STUDY OF OLDER WOMEN - 5-YEAR FOLLOW-UP [J].
BISGARD, KM ;
FOLSOM, AR ;
HONG, CP ;
SELLERS, TA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 139 (10) :990-1000
[6]
Incidence of fractures compared to cardiovascular disease and breast cancer: the Women's Health Initiative Observational Study [J].
Cauley, J. A. ;
Wampler, N. S. ;
Barnhart, J. M. ;
Wu, L. ;
Allison, M. ;
Chen, Z. ;
Hendrix, S. ;
Robbins, J. ;
Jackson, R. D. .
OSTEOPOROSIS INTERNATIONAL, 2008, 19 (12) :1717-1723
[7]
Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis [J].
Chesnut, CH ;
Skag, A ;
Christiansen, C ;
Recker, R ;
Stakkestad, JA ;
Hoiseth, A ;
Felsenberg, D ;
Huss, H ;
Gilbride, J ;
Schimmer, RC ;
Delmas, PD .
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (08) :1241-1249
[8]
Secular trends in the incidence of hip and other osteoporotic fractures [J].
Cooper, C. ;
Cole, Z. A. ;
Holroyd, C. R. ;
Earl, S. C. ;
Harvey, N. C. ;
Dennison, E. M. ;
Melton, L. J. ;
Cummings, S. R. ;
Kanis, J. A. .
OSTEOPOROSIS INTERNATIONAL, 2011, 22 (05) :1277-1288
[9]
Smoking, smoking cessation, and risk of hip fracture in women [J].
Cornuz, J ;
Feskanich, D ;
Willett, WC ;
Colditz, GA .
AMERICAN JOURNAL OF MEDICINE, 1999, 106 (03) :311-314
[10]
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].
Cummings, SR ;
Black, DM ;
Thompson, DE ;
Applegate, WB ;
Barrett-Connor, E ;
Musliner, TA ;
Palermo, L ;
Prineas, R ;
Rubin, SM ;
Scott, JC ;
Vogt, T ;
Wallace, R ;
Yates, AJ ;
LaCroix, AZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082