An efficient catalytic stereoselective route to a key intermediate for the synthesis of the long-lived PGI(2) analog ZK 96480 (Cicaprost(TM))

被引:28
作者
Corey, EJ
Helal, CJ
机构
[1] Dept. of Chem. and Chemical Biology, Harvard University, Cambridge
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(97)01803-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An expeditious and stereoselective synthesis of a key chiral intermediate (2) for the synthesis of the therapeutically useful PGI(2) analog Cicaprost(TM) is described. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:7511 / 7514
页数:4
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