Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast

被引：48

作者：

Ding, Lei

Kleer, Celina G.

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-06-2384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Amplification of the Polycomb group transcriptional repressor Enhancer of Zeste 2 (EZH2) occurs in various malignancies including breast cancer, where its overexpression is associated with poor outcome. We found that EZH2 is up-regulated in ductal carcinoma in situ, atypical ductal hyperplasia, and even morphologically normal breast. epithelial cells from women who have an increased risk of breast cancer. This review discusses how EZH2 may promote neoplastic conversion and it surveys the evidence suggesting that EZH2 may offer a clinical tool to help identify patients at risk for developing breast cancer before precursor lesions are histologically evident.

引用

页码：9352 / 9355

页数：4

共 29 条

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