Contribution of human leukocyte antigens to the antibody response to hepatitis B vaccination

被引:97
作者
McDermott, AB
Zuckerman, JN
Sabin, CA
Marsh, SGE
Madrigal, JA
机构
[1] ROYAL FREE HOSP, ANTHONY NOLAN RES INST, LONDON NW3 2QG, ENGLAND
[2] ROYAL FREE HOSP, SCH MED, ACAD UNIT TRAVEL MED & VACCINES, LONDON, ENGLAND
[3] ROYAL FREE HOSP, SCH MED, DEPT PRIMARY CARE & POPULAT SCI, LONDON, ENGLAND
[4] ROYAL FREE HOSP, SCH MED, DEPT HAEMATOL, LONDON, ENGLAND
来源
TISSUE ANTIGENS | 1997年 / 50卷 / 01期
关键词
HLA; hepatitis B vaccination; nonresponse; hepatitis B surface antigen; PreS1; PreS2; HLA-DRB1*0701; HLA-DQB1*02; HLA-DR7; HLA-DQ2;
D O I
10.1111/j.1399-0039.1997.tb02827.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We present here the analysis of 86 individuals who were true antibody nonresponders to a vaccine containing hepatitis B surface antigen. The HLA type of these individuals and of 248 controls were determined by serology for HLA class I and by molecular typing for the HLA class II loci DRB1 and DQB1, Subsequent analysis of the results revealed that HLA-DRB1*0701 and HLA-DQB1*02 were significantly associated with antibody non-response to the ''S''-containing vaccine compared with the HLA control population. Further, we found that the antibody non-response was also significantly associated with the above antigens when found in linkage disequilibrium on the HLA haplotype DRB1*0701; DQB1*0202, The hepatitis B surface antigen vaccine antibody nonresponder group, comprising 86 individuals, were revaccinated with a novel vaccine Hep B-3, containing both preS1- and preS2-derived proteins in addition to hepatitis B surface antigen? to circumvent their previous nonresponsiveness. The hepatitis B surface antigen antibody results from this group of patients show that 30 of the 86 individuals remained antibody non-responders and that 24 individuals (80%) expressed the HLA-DQB1*02 and that 21 individuals (70%) expressed HLA-DRB1*0701. Our results indicate that antibody nonresponse to the Hep B-3 vaccine is significantly associated with an extended HLA haplotype B44; DRB1*0701; DQB1*0202. A possible indication of these results is that antibody nonresponse to Hep B-3 vaccine is linked with the HLA allele DQB1*0202. These findings may have an important impact on future vaccine design.
引用
收藏
页码:8 / 14
页数:7
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