Development trends for therapeutic antibody fragments

被引：230

作者：

Nelson, Aaron L. ^{[1
]}

Reichert, Janice M. ^{[2
]}

机构：

[1] Tufts Univ, Sch Med, Boston, MA 02111 USA

[2] Tufts Ctr Study Drug Dev, Boston, MA USA

来源：

NATURE BIOTECHNOLOGY | 2009年 / 27卷 / 04期

关键词：

SINGLE-CHAIN-FV; MONOCLONAL-ANTIBODY; ESCHERICHIA-COLI; FAB FRAGMENTS; DOMAIN ANTIBODIES; FC-RECEPTOR; LOCALIZATION; MOLECULES; MELANOMA; TUMORS;

D O I：

10.1038/nbt0409-331

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Although fewer antibody fragments have entered the clinic than full-length monoclonal antibodies, proof-of-concept studies for these therapeutics remain the main hurdle.

引用

页码：331 / 337

页数：7

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