Bisphosphonates and atherosclerosis

被引：40

作者：

Ylitalo, R ^{[1
]}

机构：

[1] Univ Tampere, Sch Med, Dept Pharmacol Sci, FIN-33014 Tampere, Finland

[2] Tampere Univ Hosp, Dept Clin Chem, FIN-33521 Tampere, Finland

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 2000年 / 35卷 / 06期

关键词：

atherosclerosis; bisphosphonates; artery; macrophages; calcium; cardiovascular disease;

D O I：

10.1016/S0306-3623(01)00121-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bisphosphonates are used for the treatment of bone resorption, hypercalcemia, osteoporosis and Paget's disease. Etidronate, pamidronate and clodronate also inhibit the development of experimental atherosclerosis without altering serum lipid profile. Bisphosphonates inhibit the arterial calcification, lipid accumulation and fibrosis. They accumulate extensively in arterial walls and suppress macrophages in atheromatous lesions. In macrophage cultures, bisphosphonates inhibit the cellular accumulation and degradation of atherogenic LDL-cholesterol and foam cell formation. Further, they inhibit various enzymes involved in cell signal transduction and cholesterol biosynthesis. Recently, etidronate has been shown to inhibit the thickening of carotid arterial wall even in man. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：287 / 296

页数：10

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