Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease.: Part 3:: Potency and plasma stability

被引：25

作者：

Borthwick, AD ^{[1
]}

Exall, AM ^{[1
]}

Haley, TM ^{[1
]}

Jackson, DL ^{[1
]}

Mason, AM ^{[1
]}

Weingarten, GG ^{[1
]}

机构：

[1] CVU UK, Dept Med Chem, GlaxoSmithKline Res & Dev, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(02)00294-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mechanism-based inhibitors of HCMV protease, which Lire stable to human plasma (greater than or equal to20h) and have single-figure potency in the muM range against HCMV protease, have been developed based on the dansylprohne alpha-methyl pyrrolidine-5,5-translactam nucleus. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1719 / 1722

页数：4

共 9 条

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