Progressive depletion of mtDNA in mitochondrial myopathy

被引：11

作者：

Durham, Steve E. ^{[1
]}

Brown, Denise T. ^{[1
]}

Turnbull, Douglass M. ^{[1
]}

Chinnery, Patrick F. ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Med, Mitochondrial Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NEUROLOGY | 2006年 / 67卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1212/01.wnl.0000227961.55640.2f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied seven patients with mitochondrial DNA ( mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.

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页码：502 / 504

页数：3

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