Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1β levels

被引：15

作者：

Boelens, JJ

Zaat, SAJ

Murk, JL

Weening, JJ

van der Poll, T

Dankert, J

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 03期

关键词：

D O I：

10.1128/IAI.68.3.1692-1695.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 beta) production was found. Apparently, sustained levels of IL-1 beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

引用

页码：1692 / 1695

页数：4

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